Formulation, Characterization, and In Vitro Evaluation of Silymarin-Loaded Lipid Microspheres

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Formulation and In Vitro Evaluation of Rifampicin Loaded Porous Microspheres

Rifampicin (RIF) is a major component in fixed dose combination therapy for the treatment of tuberculosis. RIF has low solubility and high permeability with high dose and hence it is classified as class II drug in Biopharmaceutical Classification System (BCS). RIF has poor and variable bioavailability because of its poor solubility, acid decomposition and, drug and food interaction. The present...

متن کامل

Formulation, physicochemical characterization and in vitro evaluation of human insulin-loaded microspheres as potential oral carrier

The objective of the present investigation was to formulate and characterize the human insulin entrapped Eudragit S100 microspheres containing protease inhibitors and to develop an optimized formulation with desirable features. A w/o/w multiple emulsion solvent evaporation technique was employed to produce microspheres of human insulin using Eudragit S-100 as coating material and polyvinyl alco...

متن کامل

Floating microspheres of cimetidine: formulation, characterization and in vitro evaluation.

The present study involves preparation and evaluation of floating microspheres with cimetidine as model drug for prolongation of gastric residence time. The microspheres were prepared by the solvent evaporation method using polymers hydroxypropylmethyl cellulose and ethyl cellulose. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron mic...

متن کامل

Cefpodoxime Proxetil Floating Microspheres: Formulation and In Vitro Evaluation

      The objective of the present study was to develop floating microspheres of cefpodoxime proxetil in order to achieve an extended retention in the upper GIT, which may result in enhanced absorption and thereby improved bioavailability. The microspheres were prepared by non-aqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose (HPMC K 15 M), ethyl cellulo...

متن کامل

Gastroretentive Orlistat Microspheres: Formulation, Characterization, and In Vitro Evaluation

The present study involves the preparation and evaluation of floating microspheres of orlistat for improving drug bioavailability by prolongation of gastric residence time. The microspheres were prepared by a solvent diffusion–evaporation technique using inert polymers (Eudragit RL100, cellulose acetate, and ethyl cellulose). The effect of three formulation variables (i.e., drug/polymer ratio [...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Drug Delivery

سال: 2004

ISSN: 1071-7544,1521-0464

DOI: 10.1080/10717540490433958